Ritonavir (Norvir), a critical HIV protease inhibitor used in antiretroviral therapy, primarily as a “booster” to increase levels of other protease inhibitors by inhibiting the CYP3A4 enzyme, slowing drug metabolism. This medication, a white to off-white powder, is essential for treating HIV/AIDS and sometimes Hepatitis C, often combined with other drugs like lopinavir, and available in various formulations.
- Name: Ritonavir (Norvir)
- Function: HIV Protease Inhibitor, pharmacokinetic enhancer (booster) for other PIs.
- Mechanism: Inhibits Cytochrome P450 3A4 (CYP3A4), a liver enzyme that breaks down many drugs, boosting their effectiveness.
- Use: Part of antiretroviral therapy (ART) for HIV/AIDS; also used for Hepatitis C.
- Chemical Formula:
C37H48N6O5S2cap C sub 37 cap H sub 48 cap N sub 6 cap O sub 5 cap S sub 2
𝐶37𝐻48𝑁6𝑂5𝑆2
.
- Molecular Weight: 720.94.
- Forms: Capsules, liquid formulations.
- Availability: Prescription medication, also sold as research chemical standards.
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